产品货号：
Z11085
中文名称：
APH1A抗体
英文名称：
Anti-APH1A Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-APH1A Antibody |
| 指标别名 | 6530402N02Rik;APH 1A;Aph 1alpha;APH1A;CGI 78;Gamma secretase subunit APH 1A;PSF;UNQ579/PRO1141 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | APH1A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | APH1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human APH1.The immunogen is located within amino acids 80 - 130 of APH1. |
| 计算分子量 | 29kDa |
| 成分 | APH1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | APH1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | APH1 was initially identified as a component of the Notch pathway in C.elegans.Along with nicastrin,PEN2,and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease.APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex.Mice deficient in this isoform,but not the other two,were lethal at E10.5,with impaired vascular and neural development observed. |
| Uniprot ID | Q96BI3 |
| 基因名全称 | Anterior pharynx defective 1 homolog A (C.elegans) |
| 蛋白名全称 | Anterior pharynx defective 1 homolog A (C.elegans) |
| 推荐稀释比 | APH1 antibody can be used for detection of APH1 by Western blot at 0.5 ～ 1μg/mL.Despite its predicted molecular weight,APH1 protein often migrates at aberrant locations in SDS-PAGE.Antibody can also be used for immunohistochemistry starting at 5μg/mL.Antibody validated:Western Blot in mouse samples and Immunohistochemistry in human samples.All other applications and species not yet tested. |
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